Genetics and Non-Genetics of Temperament

Some fish are shy, some honeybees are outgoing. What makes individuals out of a uniform genetic background?

Do flies have personalities? Apparently so. Drosophila have a long and storied history as perhaps the greatest model organism for genetic research. They have brains, intricate development, complex bodies and behaviors, but also rapid generation time, relatively easy handling, and mass rearing. A new paper describes a quest to define their personalities- behavioral traits that vary despite a uniform genetic background. Personality is a trait that may be genetically influenced, but may just as well have environmental or sporadic causes (that is, not determined by outside factors). Importantly, this kind of trait tends to recur in a population, indicating that while it may not be determined, it follows certain canalized pathways in development, which might themselves be amenable to genetic investigation. Human personality studies have a long history, with various systems trying to make sense of the typical forms and range of variation.

A recent paper did a massive screen of uniformly inbred flies for personality variations. Computerization and automation have revolutionized the animal screening field, as it has so many others, so now flies can be indivually put through a battery of tests with minimal effort to humans, looking for their individual responses to light, to maze choices, spontaneous activity, circadian preferences, sensitivity to odors, etc. These tests were compiled for hundreds of genetically identical flies from birth to death, followed by sequencing of their mRNA expression to see which genes were active. Another batch of more diverse wild-type flies were tested as well to compare what variable genetic influences might be afoot.

Firstly, the differences they observed in these flies were stable over time. They represent true "types" of behavior, despite the lack of genetic input. Secondly, they are limited in landscape. Those flies more active in one test tend to be more active in other tests as well. So the variations in behavior seem to flow from deep-seated categorical types that follow typical patterns within fly development. Which tests should yield correlated scores, and which other ones are more orthogonal, is a little hard to figure out and a matter of subjective taste, so these conclusions about wide-spread correlations in disparate behaviors reflecting personality types is based largely on these researchers knowing their flies on a pretty intimate basis.

A matrix of videos of flies just strolling along, captured by these researchers. Not all flies walk the same way.

For example, they emphasize correlations where they would not have expected them- between, say light sensitivity and overall activity- and non-correlations where they would have expected correlation- say between activity measures of maze walking and free activity. The main observation is that there were a lot of variations among these identical-twin flies. So, just as identical humans can have different personalities, sensitivities, and outlooks, so can flies. 

Is there anything one can say about this genetically? The behavioral variations were themselves not genetically based, but rather due to alternate paths taken down developmental pathways, via either sporadic or experience-based differences. The flies were raised in the same homes, so to speak, but as we know from humans, however similar things may seem on the outside, the individual subjective experience can be very different. At any rate, the developmental pathways leading to the variations are themselves genetically determined, so this exercise was really about learning about how they work, and what range of variation they support/allow.

This analysis of course boils down to how informative the behavioral traits are that the researchers are testing. And obviously, they were not very informative- how does one connect a propensity to turn left when going down a maze with some developmental process? These researchers threw a bunch of statistics at their data, including from the gene expression analysis performed in the sacrificed flies after their mortal trials were over. For instance, among known molecular pathways, metabolic pathway gene expression correlated with activity assays of behavior- not a big surprise. Expression of photo-transduction related genes also correlated with response to light. The biggest correlation was between oxidative phosphorylation gene expression (i.e. mitochondrial activity) with their various activity measurements, which were, after all, the essence of all their assays. In humans, some people are just high-energy, which informs everything they do.

"We found that in all cases, behavioral variation has high dimensionality, that is, many independent axes of variation."

In the end, they conclude that, yes, flies of identical genetic background grow up to have distinct behavioral profiles, or one can say, personalities. Many of these behavioral profiles or traits are independent of each other, indicating several, or even numerous, axes of development where such differences can arise. The researchers estimate 27 dimensions of trait variability, in fact, just from this smattering of tests. But others vary together, forming a sort of personality type, though the choice of assays was obviously very influential in these cross-correlations. These results give a very rough start to the project of figuring out where animal development is less than fully determined, and can thus give rise to the non-genetic variation that provides rich fodder for environmental and social adaptation / specialization. While genes are not directly responsible for this variation, they are responsible for the available range, and thus set the parameters of possible adaptation.

It is sadly typical that these researchers disposed of about 1/3 of their flies at the outset of the study for being insufficiently active. While they are surely correct that these flies would continue to be less active through the rest of the assays, thus giving less data to their automated tests, they did not ask themselves why some flies might choose to think before they leap - so to speak. Were they genetically defective? The flies were identical to a matter of a handful of single nucleotide variations. If inbreeding was a problem, all the flies would have been equally affected. So it is likely that one of the most significant personality traits was summarily excluded out of raw institutionalized bias against the more introverted fly, conveniently veiled by claims of technical limitations. Hey hey, ho ho!

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Remembrance of Climates Past

As the climate heats up, we are heading back in time, very rapidly.

Climate change is the challenge of our times and of our planet. However attractive it is to not care, to ignore it, to hide in traditional ways of thinking, to let inertia have its way, inexorable change getting worse by the year. The American way of life can not go on, and will not go on as before. This year has been a remarkable demonstration of the range of catastrophe, from melting Arctic villages to Pacific Northwest heat waves, California wildfires, record draught on the Colorado river, hurricanes running out of letters, and catastrophic floods in Europe. Migration crises around the world point to another implication- that as the global South becomes unlivable, increasing hordes of people will be knocking on the borders of the Northern countries, who have authored the mess.

To get some perspective on the change, we can look backwards into the geological record to see where we are going, and how fast. Earth has had a very diverse climatic history, from its beginning in a Venus-like cloud of high CO2 and no oxygen, to "snowball earth" freezes, to torrid warm periods extending to the poles. Over the last few billion years, earth's climate has had a fundamentally, if slowly, self-correcting mechanism based on CO2 production and consumption. CO2, needless to say at this point, is the main variable in our atmosphere's tendency to retain or give up solar heat. Volcanoes liberate CO2 from geologic and organic buried carbon. Organic carbon can also be liberated by fires and decomposition of organic carbon, including exposed coal, methane, and oil deposits. On the other hand, the biosphere fixes and buries carbon, and on an even more vast scale the weathering of exposed rocks drives the formation of carbonate minerals that lock up atmospheric CO2. When conditions are warm, weathering of rocks accelerates, as can organic fixation and burial, drawing down CO2. When conditions are cold, ice sheets cover the land and inhibit both organic fixation and rock weathering, allowing CO2 to build up in the atmosphere.

These cycles mean that over a scale of millions of years, earth does not get caught irretrievably (as Venus has) in an inhospitable climate. Instead, our recent ice ages ebbed and flowed, back and forth as the CO2 balance in the atmosphere responded fitfully to geologic conditions. The dramatic snowball periods, which occurred just before the Cambrian period, came to an end even though the earth-wide snow cover dramatically reduced solar absorbance. But it also reduced weathering and organic fixation of CO2, so eventually, CO2 built up to the very high levels needed to overcome the snowball effect and the climate snapped back to very warm conditions.

A key point in all of this is that climate change over earth's history has been driven geologically, and thus has been slow. Slowness has critical effects in allowing the biosphere to adapt. The typical driver is a new spate of volcanic eruptions, which release lots of CO2. This takes thousands of years to happen, so while this can be fast in geologic terms (a prime example is the Paleocene-Eocene thermal maximum, which took maybe 20,000 years to drive the climate from very warm to quite torrid, roughly 55 million years ago). However, the homeostatic mechanisms kicked in, and this torrid phase only lasted  a couple of hundred thousand years. Another example has been the slow uplift of the Tibetan plateau, which exposed a great deal of rock to weathering, thus drawing down atmospheric CO2. This is thought to have driven the cooler temperatures and glaciations of the last few million years.

A notorious exception is the K-T boundary extinction, where an asteroid hit the earth and changed the climate overnight. And life suffered correspondingly, with all the dinosaurs wiped out. (Well, all except for birds). Whatever was not pre-adapted somehow for this instant crisis failed to make it through. The stress this put on the biosphere is obvious, catastrophic, took many millions of years to recover from, and changed the trajectory of evolution dramatically.

An extremely rich graph of the last 70 million years of earth's climate, from a recent benchmark paper. Temperatures are shown on top right, while the isotopic findings that undergird them are shown on top left (temperature proxy based on oxygen isotopes) and bottom left (carbon concentration proxy based on carbon isotopes). The overall trend is correlation between the two, with CO2 the primary driver of higher temperature, and subject to swings for various geologic and biological reasons. Temperature is also affected secondarily by orbital mechanics and other factors. Even the Eocene high temperatures were driven by CO2, though the correlation is not so clear here.

What does all this mean for our current trajectory? The graph above helpfully supplies the current IPCC scenarios of temperature change, under stringent, medium, and business as usual scenarios. The temperature today (green) is already equivalent to conditions of about five million years ago. So in time machine terms, we have travelled, in the span of a century, five million years of climate history, to before the recent ice ages. We are already beyond the stringent scenario, obviously, so the only possible futures we have to look forward to are the medium and no-action scenarios, which, within the next fifty to one hundred years, will put us, in time machine terms, fourteen and forty million years into the past, respectively. And what of the century after that? CO2 stays in the atmosphere for many thousands of years, so not only do we have to reduce emissions now, we will have to remove those that have already happened. Climate stewardship will be humanity's job whether we like it or not.

The biosphere can not cope with this rate of change. While we often think in narcissistic terms of how humans will suffer, we are the lucky ones, being the most adaptable creatures ever devised by evolution. Our problems are nothing compared to the rest of the biosphere. The ability of animals to migrate or shift their ranges is highly strained by the availability of the rest of their essential networks, mostly based on plants at the base of the ecological network. And plants are not going to have the ability to migrate at these speeds and generate new ecosytems in more northerly areas. To us, the speed of climate change is slow, barely discernible on a lifetime scale. But in earth history terms, it is blindingly fast, just a blip over an asteroid impact, and far faster than normal ecosystem dynamics, let alone evolution, can cope with. Uncounted species are falling by the wayside, victims of another great extinction in earth history in this, the anthropocene geological epoch.

Time machines are exciting tropes of science fiction, allowing amazing journeys and byzantine plot twists. But usually, the outcome is not good, since changing the time line has unpredictable and sometimes catastrophic effects. Typically, a ruse is employed to extricate the heroes from the twisted plot, and everyone sighs with relief at the end when the normal time line is restored. Our climate path is not heading for such a happy ending. We are gambling, now consciously and willfully, with not only our own civilizational existence, but with the progressive and rapid degradation of the entire biosphere, on this warp-speed trip into the geological past.

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The Power of Friendship

How do you build nations without friends? Why even try?

The US has been the world policeman and hegemon for seventy years and counting, and our run is reaching its end, for both domestic reasons of political & intellectual breakdown, and foreign competition by China and the rise of authoritarian power globally. We have helped keep the peace in Europe, and have had stunning successes fostering prosperity and freedom in places such as South Korea, Japan, and Taiwan. We have had generally friendly relations with all developed nations and with many developing nations, especially those of Eastern Europe. But we have had rather sour relations with post-colonial nations like those of the Islamic world, South America, and Africa. The US inherited the mind-set, and sometimes more concrete policies and roles from the former colonial powers, failed to break from that past, and made frequent and disastrous errors in those parts of the world. Vietnam, Iraq, and Afghanistan each fit into this mold and stand as horrible failures of nation-building. (Incidentally, we had a foretaste of this imperial dilemma in the Philippines, among other formerly Spanish possessions.)

George Washington as Roman emperor, US Capitol.

For the fact is that we are not Rome. For all our early emulation of Rome- the place names, the Senate, the heroic busts and portraits- our hearts are not into imperialism. The US hegemony has been built on cooperation, not on tyranny. Rome devastated those who rebelled, leaving traumatic scars in, for example, Christian and Jewish cultures that smart to this day. While some in our military may have the stomach for harsh oppression, (see the Iraq occupation), most do not, and far less so in the broader society. So when we invade a country like, say, Afghanistan, we are not pursuing a scorched earth policy, except inadvertantly by way of our technological and intelligence blundering. Instead, we were looking for hearts and minds, for nation-building, and for prosperous development. We are looking for allies.

But security comes first. Even a relatively small militant minority, tolerated by a sullen majority, can make an occupation into hell for the US and everyone else. (Or a cross-border insurgency such as the Viet Cong, or the Taliban from Pakistan.) We have been faced with impossible choices- either fully invade and ravage the occupied country to bring it to heal, or muddle along through civil war, corruption, bad allies, and ultimately, defeat. It seems, at a very far remove, that the missing ingredient in these failures, beyond lack of cultural understanding and foresight, has been sufficiently large friendly coalitions with which to work. If one thinks back to the occupations of Europe after world war 2, the Soviets were willing to tyrannize the Eastern European countries, which was effective, and harsh. The Western countries were given much more lenient treatment, with cooperative administrations that had broad support from populations that were, even in belligerant Germany, sick of war and sick of the shattered and psychopathic dreams of the Nazis, not to mention tempered by the fate of their brethren across the iron curtain. 

The lesson ultimately is that we can not consider invading or occupying countries where we do not already have a large coalition of political support (or for some reason have dropped nuclear bombs on them). While Germany and Japan were sufficiently cowed by their military defeats to accept and capitalize on sympathetic occupying administrations, the situation in countries like Iraq has been fundamentally different. Iraq may have had a large latent desire to be rid of their ruler. But the US invasion was clearly unjust, not due to significant belligerance on Iraq's part, and devolved into a culturally tone-deaf dis-establishment of their government with no serious provision for a new one. Our friends were clowns like Ahmed Chalabi, and we failed to realize that Hussein was not just a rogue dictator, but the representative of large tribal interests and a fair proportion of Iraqi society. In the end, not even the Shia fully supported the US occupation, so the dysfunctions of friendless and weak governance turned into civil war. So, far from being saviors, we became agents of chaos. It is a template of what to avoid in the future- invasions that assume any outpouring of political support that is not already present.

This points to a larger theme in US foreign policy, which is that we need friends. Occupations of other countries will not work on our terms without a friendly attitude from most of the population. But our foreign policy more broadly will also not work without friends. The last adminstration did incalculable damage by futilely toadying to our enemies and alienating friends. But true power for the US accrues from having positive and deep friendships all over the world which lead to coalitions of partners with sympathetic understanding and common interests. The battle with China will take place mostly on the level, not of aircraft carriers and standing armies, but of soft power- cultivating friendships that stand up to bullying and authoritarianism. 

China is taking its own soft-power initiatives with its belt-and-road push to aid developing nations. This is the major competition we face, to show that the US is a functional democracy internally and externally, capable of leading the community of developed and democratic nations against a rising tide of authoritarianism. An authoritarianism which has understandable attractions to developing nations with unstable political systems and poor economic performance- which is often directly attributable to the unfair resource extraction and other imperial or quasi-imperial trade practices of the dominant capitalist powers. So, can we foster better development in small countries without forcing first world-driven rules of governance and trade? Can we be a positive influence against the scourges of drugs and corruption? Can we fund a fair share of vaccine distribution to underdeveloped countries? Can we set an example in the fight against climate change and aid other countries to do their share? We must find better and more generous ways to truly aid less developed countries and grow our coalition so that bullies do not win the game of global hegemony.

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Alzheimer's: Wnt or Lose

A molecular exploration of the causes of Alzheimer's disease.

What causes Alzheimer's disease remains a bit of a mystery, as there is no simple and single molecular explanation, as there is with, say, Huntington's disease, which is caused by a single gene defect. There is one leading candidate, however, which is the amyloid protein, one of the accumulated molecular signatures of the disease in post-mortem brains. Some genetic forms of Alzheimer's start with defects in the gene that encodes this protein, APP (amyloid precursor protein). And a protease processing system that cleaves out the toxic amyloid beta protein from the much larger original APP protein is also closely involved with Alzheimer risk. So while there are many other genetic risk factors and possible causes relating to the APP and other systems, this seems to be the dominant causal element in Alzheimer's disease.

The naming of this protein is rather backwards, focusing on the pathological roles of defective forms, rather than on what the normal protein does. But we don't really know what that normal function is yet, so have had little choice. A recent paper described one new function for the normal APP protein, which is as a receptor for a family of proteins called WNT (for wingless integration site, an obscure derivation combining findings from fly and mouse genetics). APP had long been known to interact with WNT functions, and a reduction of WNT signaling is one of the pathologic (and possibly pathogenic) hallmarks of Alzheimer's, but this seems to be the first time it has been tabbed as a direct receptor for WNT.

What is WNT? These proteins track back to the dawn of multicelled animals, where they first appear in order to orchestrate the migration and communication of cells of the blastopore. This is the invagination that performs the transition (gastrulation) from an egg-derived ball of cells to the sheets of what will become the endoderm and mesoderm on the inside, and the ectoderm on the outside. The endoderm becomes the gut and respiratory organs, the mesoderm becomes the skeleton, muscles, blood, heart, and connective tissue, and the ectoderm becomes the skin and nervous system. WNT proteins are the ligands expressed in one set of cells, and their receptors (Frizzled and a few other proteins) are expressed on other cells which are nearby and need to relate for some developmental / migration / identification, or other purpose. One other family, the NOTCH proteins and their respective cell surface receptors, have a similar evolutionary history and likewise function as core developmental cell-cell signaling and identification systems. 

Rough structure of the APP protein. The membrane  spanning portion is in teal at the bottom, showing also some key secretase protease cleavage sites, which liberate alpha and beta portions of the protein. The internal segment is at bottom, and functions, when cleaved from the rest of the protein, as a nuclear transcription activator. Above are various extracellular domains, including one for "ligand binding", which is thought by at least one research group to bind WNT. The dimerization domain can bind other APP proteins on other cells, and heparin, another binding partner is a common component of the extracellular environment.

Fast forward a billion years, and WNT family members are deeply involved in many decisions during animal development and afterwards, particularly in the brain, controlling nerve cell branching and synapse formation in adults. WNT, NOTCH, and APP are each ligand+receptor systems, where a ligand from one cell or in soluble form binds to a receptor on the surface of another cell, which "receives" the signal and can do a multitude of things in response. The usual receptors for WNT are a family of Frizzled proteins plus a bunch of other helper proteins, the receptors for NOTCH are Jagged proteins, and the APP protein is itself a receptor whose ligand has till now been unclear, though it can homodimerize, detecting APP on other cells. APP is a large protein, and one of its responses to signals is to be cleaved in several ways. Its short cell-interior tail can be cleaved, (by gamma secretase), upon which that piece travels to the nucleus and with other proteins acts as a transciption regulator, activating, among other genes, its own gene, APP. Another possible cleavage is done by alpha secretase, causing the release of soluble APP alpha (sAPPα), which has pro-survival activities for neurons and protects them against excessive activity (excito-toxicity). Lastly, beta-secretase can cleaves APP into the toxic beta (Aβ), which in tiny amounts is also neuro-protective, but in larger amounts is highly toxic to neurons, starting the spiral of death which characterizes the hollowing out of the brain in Alzheimer's disease.

The cleavages by alpha secretase and beta secretase are mutually exclusive- the cleavage sites and products overlap, so cleavage by one prevents cleavage by the other, or destroys its product. And WNT signaling plays an important role in which route is chosen. WNT signals by two methods, called canonical or non-canonical, depending on which receptor and which ligand meet. Canonical signaling is neuro-protective, opposed to Alzheimer development, and leads to alpha secretase cleavage. Non-canonical signaling tends to the opposite, leading to internalization of APP from the surface, and beta secretase cleavage which needs acidic conditions that are found in the internal endsomes where APP ends up. So the balance of WNT "tone" is critical, and is part of the miscellaneous other risk factors that make up the background for Alzheimer's disease. Additionally, cleavage by gamma secretase is needed following cleavage by beta secretase in order to make the final forms of APP beta. The gene for gamma secretase is PSEN1 (presenilin-1), mutations in which are the leading genetic cause of Alzheimer's disease. Yet these mutations have no clear relation with the activity of the resulting gamma secretase or the accumulation of particular APP cleaved forms, so this area of causality research remains open and active.

But getting back the WNT story, if APP is itself a WNT receptor, then that reinforces the centrality of WNT signaling in this syndrome. Indeed, attempts to treat Alzheimer's by reducing the toxic amyloid (APP beta) build up in various ways have not been successful, so researchers have been looking for causal factors antecedent to that stage. One clue is that a key WNT inhibitor, DKK (for dick-kopf, derived from fly genetics, which have had some prominent German practitioners), has been experimentally an effective therapy for mice with a model form of Alzheimers. DKK is an inhibitor of the canonical WNT pathway, (via the LRP6 co-receptor of Frizzled), shunting it towards more non-canonical signaling. This balance, or "tone" of WNT signaling seems to have broad effects in promoting neurite outgrowth and synapse formation, or the reverse. Once this balance is lost, APP beta induces the production of more DKK, which starts a non-virtuous feedback cycle that may form the core of Alzheimer's pathology. This cycle could be started by numerous genetic defects and influenced by other environmental risk factors, leading to the confusing nature of the syndrome (no pun intended!). And of course the cycle starts long before symptoms are apparent and even longer before autopsy can verify what happened, so getting to the bottom of this story has been hugely frustrating.

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Myth and Science

Stories we tell about how things work.

I am reading an ancient book about ancient myths, covering some of what was known of the ancient world's stories circa the mid-20th century (that is, the "developed" ancient world of Egypt, the Near East, China, India, etc.). The authors occasionally seem exasperated that their colleagues- the ancient authors of these stories and myths- do not always take their stories as seriously as scholars themselves do, after having so painstakingly learned the relevant languages, unearthed the precious tablets, papyri, inscriptions, and other sources, compared different versions, and interpreted them in light of the historical setting. No, ancient myths can be playful affairs, evolving in dramatic complexity, freely mutating to serve the needs of the moment in their mutable oral traditions. This is especially true the farther back you go into ethnographic history, such as into the stories of the Inuit and other First Peoples of North America. It is evident that ancient societies varied widely in their theological and mythological sophistication, and particularly how closely entwined these were with the centers of power.

Inuit mythologies and their custodian, the shaman.

The scholarly apparatus around myth studies has a very earnest and modernist cast, which derives from two sources. First is Christianity, which as an extreme political and social elaboration of ancient religions has progressively reified and codified its myths. Inheriting a grab-bag of disparate ancient myths and stories, Christianity shored up its social position and theological bona fides by insisting that it was all true. The more sclerotic and far-reaching its bureaucratic structure, the more tightly it held to the absolute truth of its dogmas. A second aspect was the enlightenment and the rise of scientific modernity. That world view was not interested in playful myths of psychodrama, but in hard truths of how the world really works, stripped of the colorful trappings. Competition with this world view helped to further push religious dogmas in an absolutist direction, to that point where today, both Christian Evangelicals and fundamentalist Islamists insist that their scriptures are literally true, handed down from an all-powerful god who really exists and is not fictive construct meant as a playful expression of our scientific ignorance on one hand, and our love of social drama on the other. Anthropologists took their cues from all this, assuming that the precious myths they were studying had to be expressions of a society's absolute truths, organizing principles, and deepest motivations. But perhaps they were originally ways to pass the time and enchant a few youngsters.

Science is telling stories, too. Are they really so different? On the one hand, our need to orient ourselves in the world remains unchanged from ancient times, so the core purpose of explaining reality and society through complicated tales of causes and effects remains. And to a lay person, the explanations of quantum mechanics or cosmic inflation are no less impenetrable than myths about gods and dragons. Thus the scientists who are the custodians of these stories find themselves in the ironic position of a new priesthood, cultivating the cultural narrative around origins, natural phenomena, biology, and the like, while extending these stories in systematic ways that the priests (and alchemists, and shamans, and druids) of yore could only dream about, if they could even conceive of such reliable beliefs untethered from social drama and social control. But today's scientists can't and won't inject ancillary drama into these stories, so they will remain split off from their traditional roles and uses.

So the telling of dramatic stories and the consequent management of society through the narratives of origins, myths, and meaning- if ancient myths really did fulfill these functions, which is perhaps an anachronistic construction on our part, or at least varied widely with the nature of ancient societies- are skills having nothing, really, to do with the scientific enterprise of today, and thus nothing to do with this new priesthood. Who takes these roles?

Theology would seem the natural place for the living and socially relevant myth. But theology has split definitively from science, from history, and indeed from reality, nurturing narratives that are absurd while claiming they are true, and which in their antiquity and provincialism are impossibly remote from our current concerns, morals, and social ability to relate even allegorically. Theology has thus become lost in a sterile wilderness, doomed to be cut off from its mythical and social power. Even the more liberal and elastic precincts, if they do not insist on absolute literal truth, adhere to the crusty old stories of the Bible, which while occasionally artistic, are mostly a maddening hodgpodge and, frankly, boring. What was riveting in antiquity about lengthy ancestor lists, angry gods, virgin births, and ascending into the clouds is ridiculous today. 

The story-telling mantle has obviously been taken over by Hollywood- by the Marvel series, Star Treks, Star Wars, Potter series, and similar epics of modern fantasy. They bend reality in classically mythical ways, make up their own theology as they go along, (and throw it away as casually with the next installment), and communicate constantly updated social mores. The graphics are otherworldly, the stories and morals are updated, but the fundamental sophistication of these stories can't really be said to have advanced much. They are speaking to human nature, after all- a conversation between our inborn archetypes and the social and technological conditions we find ourselves in.

The key point is that Hollywood myths are taken as intended- as fertile and mind-expanding fantasies with social and moral lessons that are (hopefully) beneficial and relevant for our times. They are not trying to claim their myths as true- that would be absurd. Thus they do not collide with either scientific or theological claims, and use myth as it was originally and truly intended- as the dreamlike realm of symbolic human drama, full of lessons, yes, but not scientific ones, or even pseudoscientific ones.

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