The Submission Drive

Humans have a drive for social and intellectual submission, which is extremely dangerous.

There was a time when psychological "drives" were all the rage. The idea that humans have instincts much as other animals do was just entering the scientific consciousness, so finding and classifying them was an important task- the great work of figuring out the human unconscious, or subconscious. Drives for food, security, sex, dominance, and much else were found. Freud even elaborated a "death drive". But our current political epoch suggests another one- a submission drive.

To an independent minded scholar and skeptic, the behavior on the Republican side of the political spectrum is revolting. Falling all over themselves to fawn over a narcissistic megalomaniac? Check. Thinking nothing of flagrant corruption that makes Warren Harding look like a choir boy? Check. Explaining away gross incompetence and pointless cruelty across the entire policy space from economics to foreign policy? Check. What causes people to join and defend what amount to cults? For that matter, what causes people to join religions?

At one level, submission is eminently rational. Groups are always more powerful than individuals. The American archetype of the loner, the Clint Eastwood or John Wayne character riding alone to mete out justice and bucking the system- that is a fantasy. It is powerful precisely because it is so romantic and unrealistic. It is compensatory psychic food for the hemmed-in and submissive. In reality, the system always wins. Militaries win when they can gather up a bigger army than the other guys. Corporations win when they have bought all their competition and become the biggest on the block. Our social instincts lead us to join groups to gain power. 

But the submission drive seems to go way beyond this, allowing us to swallow alternate realities and even seek domination by others. An interesting form is when whole cultures convert their religion. Many times, such as during the colonial era, during the Christian conquests of Northern Europe, and during the Muslim conquests, the winning power foists its religion on another culture, a culture that grows quite rapidly to accept and adopt it as its own. Was one religion true-er or better than the other? Not at all. The new one is often significantly worse in many dimensions than the old. This is purely a power transaction where those who had submitted themselves to one archetype and narrative of cultural and supernatural power find themselves convinced that social and military coercion is a pretty important form of power too, perhaps signifying a new narrative that they should submit to. But once converted, the same psychic events happen. Leaders are idolized, scriptures are memorized, vestments are accessorized. In return, those who submit seek safety and guidance, buying into a (new) father figure archetype.

Joining a group inserts you into a hierarchy of domination. There are rewards for working your way up the ranks, being able to get others to serve you, having more influence and status. This most obvious in the military, with its obsession with colorful gradations, decorations, and uniforms. But it is true everywhere- in corporations, politics, organized crime, families. Submission is the price of entry, and it seems that to properly submit, one has to take on the a great deal more than just a signed contract. Members of organizations are constantly being tested for their loyalty, their buy-in to the ethics and goals of the organization, and its wider world-view. At IBM, they used to sing the company song. Modern corporate life is a complex compromise where some of the submittee's personal life is allowed to be separated from corporate control, and many boundaries are set by legal regime to prevent the organization from turning into a criminal entity and bar total domination of its employees, customers, business partners. 

However, other organizations are not so limited. Religion and politics are a bit less hemmed-in, and demand sometimes extraordinary kinds of fealty for the rewards on offer. In their variety of styles and cultures, they attract different temperaments of devotee. Overall, one has to say that people more prone to submission and participation in hierarchies tend to go to right-wing political, military, and religious organizations. Contrary to the cultivated image of hard-headedness and independence, conservatives turn out to submit more readily to domination by others. It is notorious that organizing Democrats is like herding cats. Likewise, university faculty tend towards independence and disorganization. Liberal churches are notoriously light on discipline and free with their theology. 

Conversely, Republican and conservative organizations spring up like weeds and have, aside from gobs of funding, remarkable discipline. The MAGA swoon for the current president is just one example of the lengths to which thought patterns can be bent in favor of the dominant leader of the moment. The corollary of greater mental submission by the followers is greater rewards and wider scope of action for the leaders. Making it to the top of such disciplined heap seems to turn psychology on its head, from submission to domination. Napoleon is a case study, working his way up the ranks, literally, to a position of ultimate power. Which promptly went to his head, causing him to veer in a conservative direction, and to wreck half of Europe. Cult leaders have time and again shown how poorly adapted we are to this much-sought after, but rarely successful, psychological transition.

The fascist/authoritarian moment that is glowering around the world has reactivated these extreme domination/submission dynamics, such as between Russia and Ukraine, and within so many far-right movements and the poitical systems they target. Fortunately, there are just fundamental temperamental barriers to the attractiveness of such movements, forcing them to take extra-legal measures if they are truly dedicated to overcome the resistence of the less submissive members of their societies.

• Much of this is drawn from a classic book, "Instincts of the Herd in Peace and War".
• Report card on the courts.
• Waymo is hitting the highway.
• Plastic.

Dopamine: Get up and Go, or Lie Down and Die

The chemistry of motivation.

A recent paper got me interested in the dopamine neurotransmitter system. There are a limited number of neurotransmitters, (roughly a hundred), which are used for all communication at synapses between neurons. The more common transmitters are used by many cells and anatomical regions, making it hazardous in the extreme to say that a particular transmitter is "for" something or other. But there are themes, and some transmitters are more "niche" than others. Serotonin and dopamine are specially known for their motivational valence and involvement in depression, schizophrenia, addiction, and bipolar disorder, among many other maladies.

This paper described the reason why cancer patients waste away- a syndrome called cachexia. This can happen in other settings, like extreme old age, and in other illnesses. The authors ascribe cachexia (using mice implanted with tumors) to the immune system's production of IL6, one of scores of cytokines, or signaling proteins that manage the vast distributed organ that is our immune system. IL6 is pro-inflammatory, promoting inflammation, fever, and production of antibody-producing B cells, among many other things. These authors find that it binds to the area postrema in the brain stem, where many other blood-borne signals are sensed by the brain- signals that are generally blocked by the blood-brain barrier system.

The binding of IL6 at this location then activates a series of neuronal connections that these authors document, ending up inhibiting dopamine signaling out of the ventral tegmental area (VTA) in the lower midbrain, ultimately reducing dopamine action in the nucleus accumbens, where it is traditionally associated with reward, addiction, and schizophrenia. These authors use optically driven engineered neurons at an intermediate location, the parabrachial nucleus, (PBN), to reproduce how neuron activation there drives inhibition downstream, as the natural IL6 signal also does.  

Schematic of the experimental setup and anatomical locations. The graph shows how dopamine is strongly reduced under cachexia, consequent to the IL6 circuitry the authors reveal.

What is the rationale of all this? When we are sick, our body enters a quite different state- lethargic, barely motivated, apathetic, and resting. All this is fine if our immune system has things under control, uses our energy for its own needs, and returns us to health forthwith, but it is highly problematic if the illness goes on longer. This work shows in a striking and extreme way what had already been known- that prominent dopamine-driven circuits are core micro-motivational regulators in our brains. For an effective review of this area, one can watch a video by Robert Lustig, outlining at a very high level the relationship of the dopamine and serotonin systems.

Treatment of tumor-laden mice with an antibody to IL6 that reduces its activity relieves them of cachexia symptoms and significantly extends their lifespans.

It is something that the Buddhists understood thousands of years ago, and which the Rolling Stones and the advertising industry have taken up more recently. While meditation may not grant access to the molecular and neurological details, it seems to have convinced the Buddha that we are on a treadmill of desire, always unsatisfied, always reaching out for the next thing that might bring us pleasure, but which ultimately just feeds the cycle. Controlling that desire is the surest way to avoid suffering. Nowhere is that clearer than in addiction- real, clinical addictions that are all driven by the dopamine system. No matter what your drug of choice- gambling, sugar, alcohol, cocaine, heroin- the pleasure that they give is fleeting and alerts the dopamine system to motivate the user to seek more of the same. There are a variety of dopamine pathways, including those affecting Parkinson's and reproductive functions, but the ones at issue here are the mesolimbic and mesocortical circuits, that originate in the midbrain VTA and extend respectively to the nucleus accumbens in the lower forebrain, and to the cerebral cortex. These are integrated with the rest of our cognition, enabling motivation to find the root causes of a pleasurable experience, and raise the priority of actions that repeat those root causes. 

So, if you gain pleasure from playing a musical instrument, then the dopamine system will motivate you to practice more. But if you gain pleasure from cocaine, the dopamine system will motivate you to seek out a dealer, and spend your last dollar for the next fix. And then steal some more dollars. This system shows specifically the dampening behavior that is so tragic in addictions. Excess activation of dopamine-driven neurons can be lethal to those cells. So they adjust to keep activation in an acceptable range. That is, they keep you unsatisfied, in order to allow new stimuli to motivate you to adjust to new realities. No matter how much pleasure you give yourself, and especially the more intense that pleasure, it is never enough because this system always adjusts the baseline to match. One might think of dopamine as the micro-manager, always pushing for the next increment of action, no matter how much you have accomplished before, no matter how rosy or bleak the outlook. It gets us out of bed and moving through our day, from one task to the next.

In contrast, the serotonin system is the macro-manager, conveying feelings of general contentment, after a life well-lived and a series of true accomplishments. Short-circuiting this system with SSRIs like prozac carries its own set of hazards, like lack of general motivation and emotional blunting, but it does not have the risk of addiction, because serotonin, as Lustig portrays it, is an inhibitory neurotransmitter, with no risk of over-excitement. The brain does not re-set the baseline of serotonin the same way that it continually resets the baseline of dopamine.

How does all this play out in other syndromes? Depression is, like cachexia, at least in part syndrome of insufficient dopamine. Conversely, bipolar disorder in its manic phase appears to involve excess dopamine, causing hyperactivity and wildly excessive motivation, flitting from one task to the next. But what have dopamine antagonists like haloperidol and clozapine been used for most traditionally? As anti-psychotics in the treatment of schizophrenia. And that is a somewhat weird story. 

Everyone knows that the medication of schizophrenia is a haphazard affair, with serious side effects and limited efficacy. A tradeoff between therapeutic effects and others that make the recipient worse off. A paper from a decade ago outlined why this may be the case- the causal issues of schizophrenia do not lie in the dopamine system at all, but in circuits far upstream. These authors suggest that ultimately schizophrenia may derive from chronic stress in early life, as do so many other mental health maladies. It is a trail of events that raise the stress hormone cortisol, which diminishes cortical inhibition of hippocampal stress responses, and specifically diminishes the GABA (another neurotransmitter) inhibitory interneurons in the hippocampus. 

It is the ventral hippocampus that has a controlling influence over the VTA that in turn originates the relevant dopamine circuitry. The theory is that the ventral hippocampus sets the contextual (emotional) tone for the dopamine system, on top of which episodic stimulation takes place from other, more cognitive and perception-based sources. Over-activity of this hippocampal regulation raises the gain of the other signals, raising dopamine far more than appropriate, and also lowering it at other times. Thus treating schizophrenia with dopamine antagonists counteracts the extreme highs of the dopamine system, which in the nucleus accumbens can lead to hallucinations, delusions, paranoia, and manic activity, but it is a blunt instrument, also impairing general motivation, and further reducing cognitive, affect, parkinsonism, and other problems caused by low dopamine that occurs during schizophrenia in other systems such as the meso-cortical and the nigrostriatal dopamine pathways.

Manipulation of neurotransmitters is always going to be a rough job, since they serve diverse cells and pathways in our brains. Wikipedia routinely shows tables of binding constants for drugs (clozapine, for instance) to dozens of different neurotransmitter receptors. Each drug has its own profile, hitting some receptors more and others less, sometimes in curious, idiosyncratic patterns, and (surprisingly) across different neurotransmitter types. While some of these may occasionally hit a sweet spot, the biology and its evolutionary background has little relation to our current needs for clinical therapies, particularly when we have not yet truly plumbed the root causes of the syndromes we are trying to treat. Nor is precision medicine in the form of gene therapies or single-molecule tailored drugs necessarily the answer, since the transmitter receptors noted above are not conveniently confined to single clinical syndromes either. We may in the end need specific, implantable and computer-driven solutions or surgeries that respect the anatomical complexity of the brain.

• Thoughts about corruption.
• The Fed is extraordinarily powerful.
• But our Stable Genius is going downhill.
• The real deal with autism.

Gold Standard

The politics and aesthetics of resentment. Warning: this post contains thought crime.

I can not entirely fathom thinking on the right these days. It used to be that policy disputes occured, intelligent people weighed in from across a reasonable spectrum of politics, and legislation was hammered out to push some policy modestly forward (or backward). This was true for civil rights, environmental protection, deregulation, welfare reform, even gay marriage. That seems to be gone now. Whether it is the atomization of attention and thought brought on by social media, or the mercenary propaganda of organs like FOX news, the new mode of politics appears to be destructive, vindictive spite. A spiral of extremism.

It also has a definite air of resentment, as though policy is not the point, nor is power, entirely, but owning the libtards is the real point- doing anything that would be destructive of liberal accomplishments and ideals. We know that the president is a seething mass of resentments, but how did that transform alchemically into a political movement?

I was reading a book (Deep South) by Paul Theroux that provides some insight. It is generally a sour and dismissive, full of a Yankee's distain for the backwardness of the South. And it portrays the region as more or less third world. Time and again, towns are shadowed by factories closed due to off-shoring.  What little industry the South had prior to NAFTA was eviscerated, leaving agriculture, which is increasingly automated and corporatized. It is an awful story of regression and loss of faith. And the author of this process was, ironically, a Southerner- Bill Clinton. Clinton went off to be a smarty-pants, learned the most advanced economic theories, and concluded that NAFTA was a good deal for the US, as it was for the other countries involved, and for our soft power in the post-world war 2 world. The South, however, and a good deal of the Rust Belt, became sacrifice zones for the cheaper goods coming in from off-shore.

What seemed so hopeful in the post-war era, that America would turn itself into a smart country, leading the world in science, technology, as well as in political and military affairs, has soured into the realization that all the smart kids moved to the coasts, leaving a big hole in the middle of the country. The meritocracy accomplished what it was supposed to, establishing a peerless educational system that raised over half the population into the ranks of college graduates. But it opened eyes in other ways as well, freeing women from the patterns of patriarchy, freeing minorities from reflexive submission, and opening our history to quite contentious re-interpretation. And don't get me started on religion!

So there has been a grand conjunction of resentment, between a population sick of the dividends of the educational meritocracy over a couple of generations, and a man instinctively able to mirror and goad those resentments into a destructive political movement. His aesthetic communicates volumes- garish makeup, obscene ties, and sharing with Vladimir Putin a love of gold-gilded surfaces. To the lower class, it may read expensive and successful, but to the well educated, it reeks of cheapness, focusing on surface over substance, a bullying, mob aesthetic, loudly anti-democratic.

Reading the project 2025 plans for this administration, I had thought we would be looking at a return to the monetary gold standard. But no, gold has come up in many other guises, not that one. Gold crypto coins, Gold immigration card, Oval office gold, golden hair. But most insulting of all was the ordering up of gold standard science. The idea that the current administration is interested in, or capable of, sponsoring high quality personnel, information or policy of any kind has been thoroughly refuted by its first months in office. The resentment it channels is directed against, first and foremost, those with moral integrity. Whether civil servants, diplomats, or scientists, all who fail to bend the knee are enemies of this administration. This may not be what the voters had in mind, but it follows from the deeper currents of frustration with liberal dominance of the meritocracy and culture.

But what is moral integrity? I am naturally, as a scientist, talking about truth. A morality of truth, where people are honest, communicate in truthful fashion, and care about reality, including the reality of other people and their rights / feelings. As the quote has it, reality has a well-known liberal bias. But it quickly becomes apparent that there are other moralities. What we are facing politically could be called a morality of authority. However alien to my view of things, this is not an invalid system, and it is central to the human condition, modeled on the family. Few social systems are viable without some hierarchy and relation of submission and authority. How would a military work without natural respect for authority? And just to make this philosophical and temperamental system complete, one can posit a morality of nurture as well, modeled on mothering, unconditional love, and encouragement.

This triad of moralities is essential to human culture, each component in continual dynamic tension. Our political moment shows how hypertrophy of the morality of authority manifests. Lies and ideology are a major tool, insisting that people take their reality from the leader, not their own thoughts or from experts who hew to a morality of truth. Unity of the culture is valued over free analysis. As one can imagine, over the long run of human history, the moralities of nurture and authority have been dominant by far. They are the poles of the family system. It was the Enlightenment that raised the morality of truth as an independent pole in this system for the culture at large, not just for a few scholars and clerics. Not that truth has not always been an issue in people's lives, with honesty a bedrock principle, and people naturally caring whether predicted events really happen, whether rain really falls, the sun re-appears, etc. But as an organizing cultural principle that powers technological and thus social and cultural progress, it is a somewhat recent phenomenon.

It is notable that scientists, abiding by a morality of truth, tend to have very peaceful cultures. They habitually set up specialized organizations, mentor students, and collaborate nationally and internationally. Scientists may work for the military, but within their own cultures, have little interest in starting wars. It is however a highly competitive culture, with critical reviewing, publishing races, and relentless experimentation designed to prove or disprove models of reality. Authority has its place, as recognized experts get special privileges, and established facts tend to be hard to move. At risk of sounding presumptuous, the morality of truth represents an enormous advance in human culture, not to be lightly dismissed. And the recent decades of science in the US have been a golden age that have produced a steady stream of technological advance and international power, not to mention Nobel prizes and revelations of the beauty of nature. That is a gold standard. 

• The theme does strike a nerve.
• In the name of free speech, thought crime will be punished.
• The war against propaganda.
• How fun it is in a culture of cruelty.
• A great drying is taking place.
• Is there no limit to the corruption?
• 200 years of trains.

An Uneasy Relationship With the Air

Review of Airborne, by Carl Zimmer. 

The pandemic was tough on everyone. But it had especially damaging effects on the political system, and on its relationship to the scientific community. Now the wingnuts are in charge, blowing up the health and research system, which obviously is not going to end well, whatever its defects and whatever their motivations.

While the scientific community had some astounding wins in this pandemic, in virus testing and vaccine production, there were also appalling misses. The US's first attempt at creating a test failed, at the most critical time. We were asleep at the wheel of public health, again at the earliest time, in controlling travel and quarantining travelers. But worst of all was the groupthink that resisted, tooth and nail, the aerosol nature of viral transmission of Covid. That is, at the core, what Zimmer's book is about, and it is a harrowing story.

He spends most of the book strolling through the long history of "aerobiology", which is to say, the study of microbes in the air. There are the fungal spores, the plant pests, the pollen, the vast amount of oceanic debris. But of most interest to us are the diseases, like tuberculosis, and anthrax. The field took a detour into biowarfare in the mid-20th century, from which it never really recovered, since so much of that science was secret, and in its shadow, the sporadic earlier public studies that looked carefully into disease transmission by aerosols were, sadly, forgotten. 

So it became a commonplace at the CDC and other public health entities, among all the so-called infectious disease specialists, that respiratory viruses like influenza, colds, and coronaviruses spread not by aerosols, but by contact, surfaces, and large droplets. This made infection control easy, (at least in principle), in that keeping a few feet away from sick people would be sufficient for safety, perhaps plus surgical masks in extreme situations. There was a curious disinterest in the older studies that had refuted this concept, and little interest in doing new ones, because "everyone knows" what the virus behavior is.

It is hard to explain all this in purely scientific terms. I think everyone knew at some level that the true nature of respiratory virus transmission was not well-understood, because we clearly had not managed to control it, either in residential or in hospital settings. It is hard to grapple with invisible things, and easy to settle into conventional, even mythical, trains of thought. First there were miasmas, then there were Koch's postulates and contact by fluids. It was hard to come full circle and realize that, yes, miasmas were sort of a thing after all, in the form of aerosols of infectious particles. It was also all too easy to say that little evidence supported aerosol spread, since the work that had been done had been forgotten, and the area was unfashionable for new work, given the conventional wisdom.

Even more significantly, the implications of aerosol spread of viruses are highly unpleasant, even frightening. The air we need every minute of our lives is suspect. It is a bit like the relationship we have with food- deeply conflicted and fraught, with fears, excesses, and rituals. One has to eat, but our food is full of psychological valences, possible poisons, cultural baggage, judgement, libraries full of advice. No one really wanted to go there for air as well. So I think scientists, even those calling themselves infectious disease specialists, (of all things), settled into a comfortable conventional wisdom, that droplets were the only game in town.

But what did this say about the larger research enterprise? What did it mean that, even while medical/bio research community was sequencing genomes and penetrating into obscure and complex regions of molecular biology, we had not done, or at least not appreciated and implemented, the most basic research of public health- how infectious diseases really spread, and how to protect people from them? It constituted gross negligence by the medical research community- no two ways about it. And that appears to have caused the public at large to question what on earth they were funding. A glorious enterprise of discovery, perhaps, but one that was not very focused on actual human health.

A timeline of research/policy

• Sprawling work on airborne infection in 1955. 

• Earliest glimmer in latest pandemic, May 2020. 

• Deeper followup, October 2020.

• Even deeper followup, August 2021. Later, 2023.

• Critics still can not believe aerosol spread, November, 2022.

• Hospital HVAC requirements currently go to MERV 8, not enough.

• Current CDC guidance mentions aerosols only from "procedures", not from people, though masks are recommended.

Aerosol spread of disease requires two things- that aerosols are produced, and that the infectious microbes remain infectious while in those aerosols. The former is clear enough. We sneeze, after all. Even normal breathing creates fine aerosols. The latter is where scientific doubt has been more common, since many viruses are not armored, but have loose coats and membranes derived from our own, delicate cells. Viruses like HIV don't survive in aerosols, and don't spread that way. But it turns out that Covid viruses have a half life of about two hours in aerosols. 

The implications of that are quite stunning. It means that viruses can hang around in the air for many hours. Indoor spaces with poor ventilation- which means practically all indoor spaces- can fill up with infectious particles from one or a few infected people, and be an invisible epidemic cloud. No wonder everyone eventually got Covid. 

What to do about it? Well, the earliest aerobiology experiments on infectious disease went directly to UV light disinfection, which is highly effective, and remains so today. But UV light is dangerous to us as well as microbes, so needs to be well-shielded. As part of an air handling system, though, UV light is an excellent solution. Additional research has found that far-UV, at 222 nm, is both effective against airborne microbes and safe for human eyes and skin, creating an outstanding way to clear the air. Another approach is HEPA filtration of air, either as part of an air handling / exchange system, or as stand-alone appliances. Another is better ventilation overall, bringing in more outside air, though that has high energy costs. Lastly, there are masks, which are only partially effective, and the place no one really wants to go. But given a lack of responsibility by those in charge of our built environment, masks are the lowest common denominator- the one thing we can all do to protect ourselves and others. And not just any mask, but the N95 high-quality filtration mask or respirator.

The pandemic threw some sharp light into our public institutions. We sequenced these viruses in a hurry, but couldn't figure out how they spread. We created vaccines in record time, but wasted untold effort and expense on cleaning surfaces, erecting plexiglass shields, and demanding masking, rather than taking responsibility for guarding and cleaning public air spaces in a more holistic way. It is a disconcerting record, and there remains quite a bit yet to do.

• Poor (and personalized) policy means poor science and poor vaccines.
• Department of injustice and thought crime.
• Who needs new music?
• Putin and money.
• Another argument for public schools.
• Another biological thing that didn't exist, until it did- lymph drainage in the brain.
• No wonder no one wants to become a primary care physician.
• The Japanese ice age.

Hungary for Power

Hungary has become a one-party, authoritarian state, not a democracy.

Victor Orban recently paid a visit to Donald Trump in Florida, with glowing photos and pledges of goodwill. Republicans in the US have nurtured a deep fascination and alliance with Orban and his government, holding several CPAC conventions in Hungary, and hosting Orban and his lieutenants at US events. It is clear that they view Hungary as a shining example and template of where they could take the US. Not the shining city on a hill of Reagan's democratic and anti-authoritarian dreams, but a whole other kind of city, one that never will fall into Democratic hands again.

So it is worth looking in detail at what has happened in Hungary, to observe the ideals of our current Republicans and what is in store for the rest of us from a second Trump term. I was, incidentally, beaten to the punch of this analysis by a recent story in the Atlantic. Orban's party, Fidesz, is very similar to the GOP in its mix of business right-wingery and rural values. Its strength is handing out the red meat of traditional, anti-cosmopolitan values to the rural base, along with helpful economic subsidies. In the pivotal 2018 election, it won all the rural districts, even though the opposition bowed to the logic of re-written (winner-take-all) electoral system and tried to join into a unified party. 

Fidesz came to power originally on an anti-socialist platform, vowing to get rid of the remnant bits of the prior communist system, which had settled into the same kind of semi-kleptocratic mode as in most of the former Soviet states and its satellites. That they did, but not to bring an end to corruption, let alone authoritarianism, but rather to partake themselves instead. After coming into power, Fidesz rewrote the constitution, in ways large and small to entrench their own power, and has since continued a campaign of extremely effective, gradual, and often surreptitious legislation to cement its advantages. Gerrymandering is now standard procedure, which when combined with the winner-take-all districts creates the opportunity to win overwhelming majorities in parliament founded on very thin electoral pluralities. Small parties can not win any more, but are also prohibited from combining with other small parties into election list coalitions.

The courts were remade by putting them under the control of a political appointee- the president of the National Judicial Office. This president is appointed by parliament, and in turn appoints, promotes, and runs the operations and budget of the whole judicial system. Needless to say, it is heavily influenced by the now Fidesz-controlled parliament and executive.

The media has been remade by gradual pressure on independent media owners to sell to Fidesz-friendly interests, which now control 90% of the country's media. Government advertising buys were strategically placed with friendly outlets, and government run media was put under direct political control. A Russian inspired "security" law was passed to outlaw ill-defined criticism of the state, public morality, or "imbalance" of coverage, answerable naturally to a parliamentary-appointed body, rather than the courts. Imagine if in the second Trump administration, PBS and NPR were put under political control and given a "FOX" makeover. 

Hungary is now effectively a one-party authoritarian state with managed elections. We are not far off. To see the battle of titanic interests and billionaires now openly showering money on favored candidates, and extending their tentacles down to the school board level, is sickening. The Republican party has partnered with Heritage foundation to offer an openly Orbanist plan for the second Trump administration. The court system has already re-written our constitution in extensive ways over the last four years, without an amendment being passed, or even proposed. The antics of Judge Eileen Cannon show that very little may remain of the rule of law if it is left in the hands of partisan extremists.

And our media is in even more perilous condition, with the relentless lying of FOX, Sinclair, and their ecosystem. The Republican convention just past was a pageant of lies and grift, betokening the criminal enterprise that party has turned into. Headed by their adored, and now divine, leader who is not just a felon and business fraud, but rapist and insurrectionist as well. But no matter. With enough money, and enough shamelessness, anything is possible.

• Everything is fine!
• Scandals erupt out of a corrupted system.
• The new GOP.
• Which is a blue collar party, right?
• Tom Tomorrow, on last week.
• Historical note on the great California land grab, and the fate of "free" land generally.
• Notes from the early days of life.

The Impossibility of Morality

We have dark sides and do bad things. How come we all think we are good people?

Part of our political, and temperamental, divide revolves around how seriously to take morality. How idealistic to be about goodness, how hard to try, or whether to be more realistic to be about our dark side. For all the platitudes and commandments, the sad fact is that morality is impossible, so the question is perhaps more how intensively we blind ourselves to darkness rather than how dark we will actually be.

Weird, right? But the closer you look, the more impossible it is to follow any system of morality. There are Jains who will not hurt a fly, let alone eat meat. But plants have feelings too. And our guts contain astronomical numbers of organisms in a roiling dance of macabre death. What about them? Existence as a human is unavoidably destructive. Simpler moral systems preach kindness to others. But again, existence requires feeding one's own fire, and that must come at cost to something, or someone. Every trade is unequal, even if voluntary. Employees are notoriously exploited to give more than their fair share. The Earth is relentlessly exploited. There is no end to our appetites, as long as we are alive.

Psychologically, we build up defenses to say that we are no worse than others, that we are good people. Even if we are bad people, we say that we have been driven to crime, and it is no worse than the rich people who thoughtlessly abuse others. Or if we are a presidential candidate, we say that we are saving the world, and making America great, and the subject of cruel witchhunts. Self-defense is one more essential part of living, even if it comes at the expense of seeing the world clearly. Unflattering visions of our way of life are rejected and repressed, the more so if they come as criticism from others.

Defensive blindness is integral to "modern" life. The agriculture and food processing industry keeps the slaughterhouses hidden, the feedlots and inhumane poultry coops under wraps. The less we know, the better we feel. Money is the ultimate screen against the squeems and qualms of existence, shielding us from the rapacious mining that our electronics drive in tropical forests, the slave labor that makes our clothes, and countless other immoral and destructive processes we are ultimately responsible for. Clear consciousness of all this would make the whole system collapse.

Protesters carrying the pine tree flag of Christian nationalism. While doing good things for the country.

Religions offer their own forms of defense. Confession in the Catholic church is a classic way to touch the darkness, but then to be absolved and feel good again. Exorcisms are offered as well. Protestant approaches tend to focus more on works, like community service, or in fringier precincts, on sermons of self-glorification. Everyone who is reborn in Christ is part of the club, and though a sinner, is also good, glorious, and heaven-bound. Possibly, even, in the Mormon system, himself a god. How they engage with moral darkness varies tremendously by religion, but the common need is to control it, in ourselves and others, sufficiently that our self-image of goodness and light can be preserved.

The extensive repression of moral darkness leads to the countervailing temptation to take another peek at it, under controlled conditions. It is the inspiration for much art- the detective thiller, the horror movie, the general apparatus of drama. Without darkness, there is no interest or light. And people differ markedly in their approach to such material. The more liberal and optimistic tend to focus on the light side, not the dark side, and do so politically as well. They have more moral idealism and hope, which means they have more repression of darker tendencies. Kumbaya is sung. Conversely, the more "realistic", conservative attitude scoffs at the do-gooder idealism of the left, and sees darkness around every corner- in foreigners, in sexual transgression and expression, in fluid social systems, in change itself. They recognize that moral aspiration is futile- such as the woke trend of recent times .. the bending over backwards to every minority group, micro-aggression, every insect and animal, and the climate.. is putting up an impossible and futile bar. That sticking to basics and tradition is going to get us further than such refusal to recognize the dark reality of human existence. 

These valences are apparent in the Palestinian dilemma. As the Palestinians were expelled from Israel during its establishment, the Jews proclaimed a right for Jews all over the world to come to Israel. Meanwhile, the UN created a right of return for Palestinians, to the very same land that formed Israel. It was the ultimate expression of bleeding heart unrealism, and has led (in part) to the existentially stuck misery of Palestinians for all these decades, as the UN took it upon itself to nurture an absurd dream of return and set up a now-permanent refugee apparatus of feeding, schools, and health care, all of which fuels the seething anger and terrorist dreams of ever-growing generations of Palestinians.

Another example is the US war in Vietnam- a curious and tragic mix of blindness, idealism, and realism. We wanted to help the (South) Vietnamese defend themselves from communism. In light of what happened in North Korea in the ensuing decades, this was not a bad goal. North Korea is moral darkness incarnate- a cruel and criminal dictatorship. But once the enormity of the task became clear, the moral realists took charge, with the aim of bombing Vietnam and its neighboring countries into submission. But even such extreme measures failed, leaving us with the ashes of horrible means used in the service of a futile goal. The US media was increasingly unwilling to hide the horrors, bringing into American consciousness all this darkness, which turned out to be unbearable.

So, is it better to blind ourselves to the darkness, and risk destruction and error, or better to be realistic, explore it, even celebrate it, as the Homeric epics do, and gird ourselves to deal with it, and deal it out to others? As in most things, societies are probably best off with a mix of perspectives. This mix is perennially expressed in our political spectrum, though of late the right seems to have gotten caught up in a peculiar reaction against the pieties of the left. As the left has gained the cultural and governmental high ground, as shown by the triumph of gay rights, ever-increasing concern for racial minorities, and a rising tide of official movement on environmental concerns, the right has turned apoplectic. They seem to be saying ... "We love our trucks, we won the continent fair and square, and we won the racial contest as well.."- leave us to our spoils, and don't be so concerned about "fairness" .. life isn't fair or moral, but goes to the darkest, baddest winner. (One can hear echos of the Confederate South in all this clearly enough.) Those on the left who are besotted with woke-ness and fairness will be singing a different tune when they are not at the top of the heap anymore, in their well-gentrified, rich and safe neighborhoods.

Perhaps this portrayal is extreme, but extreme concern for the moral fairness within a society can blind us to other issues, such as the competitive underpinnings of life, both within and verus other societies, and the ultimate impossibility of being totally fair, or moral, as historical actors. A balance of moral idealism and realism about unavoidable dark aspects is needed, but not in a conflict that tears the society apart. That depends on communication between the two sides, and less totalizing certainty from each side's respective mechanisms that repress doubt and screen (or valorize, in extreme cases) various different aspects of darker morality. Religion is notorious for reshaping its adherent's realities and protecting them psychologically from their own evil actions. But left wing certainty functions similarly, with its echo chambers and pieties. So, as usual, deeper insight is needed, mostly of our own blind spots and what they are hiding, but also of how such mechanisms work across the spectrum.

• Eating animals and loving them.
• Ready to be gouged more efficiently?
• Is your car really worth it?
• Corals are dying.

Eco-Economics

Adrienne Buller on greenwashing, high finance, and the failures of capitalism viz the environment, in "The Value of a Whale".

This is a very earnest book by what seems to be an environmental activist about the mistaken notion that capitalism gives a fig about climate change. Buller goes through the painstaking economic rationales by which economists attempt to value or really, discount the value of, future generations. And how poorly carbon taxes have performed. And how feckless corporations are about their climate pledges, carbon offsets, and general greenwashing. And how unlikely it is that "socially conscious" investing will change anything. It is a frustrated, head-banging exercise in deflating illusions of economic theory and corporate responsibility. Skimming through it is perhaps the best approach. Here is a sample quote from Buller's conclusion:

Given this entrenched perspective, it is unsurprising that resistance to the kinds of bold change we need to secure a habitable planetary future for all and a safe present for many tend to focus on what we stand to lose. Undeniably, available evidence suggests that 'addressing environmental breakdown may require direct downscaling of economic production and consumption in wealthier countries'. This is an uncomfortable idea to grapple with, but as philosopher Kate Soper writes: 'If we have cosmopolitan care for the well-being of the poor of the world, and a concern about the quality of life for future generations, then we have to campaign for a change of attitudes to work, consumption, pleasure, and self-realization in affluent communities.' There is a sense that this future is necessarily austerian, anti-progress, and defined by lack. Indeed, the same media study cited above found discussion of economies defined by the absence of growth to focus on bleakness and stagnation. Comparatively little attention is directed at what we stand to gain - but there is much to be gained. Understanding what requires us to ask what the existing system currently fails to provide, from universal access to health case and education, to basic material security, to free time. It certainly does not offer a secure planetary future, let alone one in which all life can thrive. And it does not offer genuine democracy, justice or freedom for most. Absent these, what purpose is 'the economy' meant to serve?

Unfortunately, the book is not very economically literate either, making its illusions something of a village of straw men. Who ever thought that Royal Dutch Shell was going to solve climate change? Who ever thought that a $5 dollar per ton tax on CO2 emissions was going to accomplish anything? And who ever thought that the only reason to address climate heating was to save ourselves a dollar in 2098? All these premises and ideas are absurd, hardly the stuff of serious economic or social analysis. 

But then, nothing about our approach to climate heating is serious. It is a psychodrama of capitalism in denial, composed of cossetted capitalist people in the five stages of grief over our glorious carbon-hogging culture. Trucks, guns, and drive-through hamburgers, please! Outright denial is only slowly ebbing away, as we sidle into the anger phase. The conservative Right, which mixes an apocalyptically destructive anti-conservative environmental attitude with a futile cultural conservatism, is angry now about everything. The idea that the environment itself is changing, and requires fundamental cultural and economic change, is an affront. The eco-conscious left is happy to peddle nostrums that nothing really has to change, if we just put up enough solar panels and fund enough green jobs. 

Objectively, given the heating we are already experiencing and the much worse heating that lies ahead, we are not facing up to this challenge. It is understandable to not want to face change, especially limits to our wealth, freedoms, and profligacy. But we shouldn't blame corporations for it. The capitalist system exists to reflect our desires and fulfill them. If we want to binge-watch horror TV, it gives us that. If we want to gamble in Las Vegas, it gives us that. If we want to drive all around the country, it makes that possible. Capitalism transmutes whatever resources are lying around (immigrant labor, publically funded research, buried minerals and carbon, etc.) to furnish things we want. We can't blame that system for fouling up the environment when we knew exactly what was going on and wanted those things it gave us, every step of the way.

No, there is another mechanism to address big problems like climate heating, and that is government. That is where we can express far-sighted desires. Not the desire for faster internet or more entertaining TV, but deep and far-reaching desires for a livable future world, filled with at least some of the animals that we grew up with, and maybe not filled with plastic. It is through our enlightened government that we make the rules that run the capitalist system. Which system is totally dependent on, and subservient to, our collective wisdom as expressed through government. 

So the problem is not that capitalism is maliciously ruining our climate, but that our government, representative as it is of our desires, has not fully faced up to the climate issue either. Because we, as a culture, are, despite the blaring warnings coming from the weather, and from scientists, don't want to hear it. There is also the problem that we have allowed the capitalists of our culture far too much say in the media and in government- a nexus that is fundamentally corrupt and distorts the proper hierarchy of powers we deserve as citizens.

The US games out in 2012 how various carbon taxes will affect emissions, given by electricity production. These are modest levels of taxation, and have modest effects. To actually address the climate crisis, a whole other magnitude of taxation and other tools need to be brought to bear. The actual trajectory came out to more renewables, no growth for nuclear power, and we are still burning coal.

Let me touch on just one topic from the book- carbon taxes. This is classic case of squeemish policy-making. While it is not always obvious that carbon pricing would be a more fair or effective approach than direct regulation of the most offensive industries and practices, it is obvious that putting a price on carbon emissions can be an effective policy tool for reducing overall emissions. The question is- how high should that price be to have the effect we want? Well, due to the universal economic consensus that carbon pricing would be a good thing, many jurisdictions have set up such pricing or capping schemes. But very few are effective, because, lo and behold, they did not want to actually have a strong effect. That is, they did not want to disrupt the current way of doing things, but only make themselves (and ourselves) feel good, with a slight inducement to moderate future change. Thus they typically exempt the most polluting industries outright, and set the caps high and the prices low, so as not to upset anyone. And then Adrienne Buller wonders why these schemes are so universally ineffective.

Carbon prices in California are currently around $30 per ton CO2, and this has, according to those studying the system, motivated one third of the state's overall carbon reductions over the current decade. That is not terrible, but clearly insufficient, even for a forward-thinking state, since we need to wring carbon out of our systems at a faster pace. Raising that price would be the most direct way for us as a society to do that. But do we want to? At that point, we need to look in the mirror and ask whether the point of our policies should be addressing climate heating in the most effective way possible, or to avoid pain and change to our current systems. Right now, we are on a sort of optimal trajectory to avoid most of the economic and social pain of truly addressing climate change, (by using gradualist and incremental policies), but at the cost of not getting there soon enough and thus incurring increasing levels of pain from climate heating itself- now, and in a future that is measured, not in years, but in centuries. 

The second big point to make about this book and similar discussions is that it largely frames the problem as an economic one for humanity. How much cost do we bear in 2100 and 2200, compared with the cost we are willing to pay today? Well, that really ignores a great deal, for there are other species on the planet than ourselves. And there are other values we have as humans, than economic ones. This means that any cost accounting that gets translated into a carbon price needs to be amplified several fold to truly address the vast array of harms we are foisting on the biosphere. Coral reefs are breaking down, tropical forests are losing their regenerative capability, and the arctic is rapidly turning temperate. These are huge changes and harms, which no accounting from an economic perspective "internalizes". 

So, we need to psychologically progress, skipping a few steps to the facing-it part of the process, which then will naturally lead us towards truly effective solutions to get to carbon neutrality rapidly. Will it cost a lot? Absolutely. Will we suffer imbalances and loss of comforts? Absolutely. But once America faces up to a problem, we tend to do a good job accepting those tradeoffs and figuring out how to get the results we want. 

• An earth systems perspective.
• I hope you are appreciating this free-range, hand-made, artisanal prose.
• Loneliness.
• Plastic is a thing too.
• Natural gas and the future of Europe.
• Maybe having cars parked everywhere isn't the best idea.
• Thoughts on the drug war.

Founders, Schmounders

Elie Mystal rakes constitutional originalism over the coals, in "A Black Guy's Guide to the Constitution".

I was raised to revere the founders and the elegant, almost scriptural document they constructed to rule our society. But suppose I was a black person, knowing that these founders were the rich white guys of their time, owners and abusers of slaves? I might think that while their aspirations were rhetorically high, their constitution was rather more utilitarian in its denial of true democracy to most people living in the colonies, its indirect and unjust approach to the democracy it did allow, and its euphemistically stated, but absolute, denial of freedom to "other persons". I would have experienced the US legal and cultural system as one of systematic oppression, dedicated to the proposition that while white, rich, men might be equal in some way and enjoy a rules-based system, the larger point of the system was to maintain power in their hands, and deny it to all others.

At least that is the sense one gets from Mystal's book, which, along with a lot of colorful language and wry jokes, assembles a trenchant rebuke of the American constitution, of conservatives, of Republicans, and especially of the originalist ideology of jurisprudence. Every hot button topic gets its due, and every amendment its contrarian interpretation. The second amendment is easy- it is about a regulated militia, after all, not about some commandment handed down from Charlton Heston to the ammosexuals of the nation to stock up on AR-15s and have a mass shooting if they are feeling a little antsy. 

Police brutality, prejudice, impunity, and immunity from accountabiliy is another easy, if painful, target. Mystal describes how he has been profiled and roughed up, for no other reason than being black. The legal system seems to have driven a semi through the fourth amendment against unreasonable searches when it comes to vehicles owned by black people, for one thing. And the fifth amendment comes into play as well- why do we allow police to play cat and mouse with suspects, trying to trip them up and get them to confess, cutting corners and playing games with their Miranda rights? Mystal makes a strong case for doing away with this whole theater of intimidation, with its slippery slope to fraud and torture, by barring police from eliciting or transmitting confessions at all, period. He notes that anyone with even a glancing acquaintance with the legal profession has learned to say nothing to police without a lawyer by her side.

Mystal's approach to abortion, however, is where this book really shines. Was Roe "wrongly decided"? Hardly. In the first place, Mystal provides an interesting discussion of "substantive" due process, (fifth amendment, and fourteenth), meaning that the rights and protections of the constitution are not to be taken merely literally or trifled with by twisting their meanings. They must be afforded by realistic means and set in a legal / civil system that supports their spirit. And that means that the right to privacy is a thing. While its poetic origin may be in the "penumbras" of the constitution, it is integral to the very idea of much of it- the concept unreasonable searches, of rights against self-incrimination, of any sort of rights of the individual vs the state. This is not to mention the ninth amendment, which asserts that just because the constitution and bill of rights mentions some rights explicitly, that others by their ommission are not covered. Privacy would, in general terms, clearly fall in this category.

But where else could a right to abortion be found? Plenty of places. One is the equal protection clause of the fourteenth amendment. Mystal, and many others, note that this should be taken as applying to women, making the whole equal rights amendment (ERA) unnecessary, given a modicum of enlightened interpretation. It could also be taken to afford men and women equal protections regarding reproduction, meaning that the penalty for a roll in the hay should not be grossly unequal, as it is when abortion is banned. Mystal goes on to suggest that the eighth amendment against cruel and unusual punishment could be invoked as well. If men were faced, as a penalty for sex, months of mental and physical torment, and then the excruciating labor of birth, one could be sure that no court would consider banning abortion for a nanosecond. And how much more cruel and vindictive is it be if that pregnancy arose from rape? There is also, after all, the thirteen amendment against involuntary servitude/labor.

Originalists brazenly throw their so-called principles out the window when it comes to abortion. Unenumerated rights? Never heard of them. Keeping the state out of the most sacred precincts of our private lives? No comment. Colonial attitudes towards abortion were very loose, nothing like the personhood-at-conception garbage we get today from the right/Catholic wing. It just goes to show that a little knowledge (here, of biology) can be a dangerous thing.

It is really originalism and conservatism, however, that is the overarching and corrosive topic Mystal takes on. The founders were people of their time, and that was a white supremacy kind of time. They wrote a constitution with hopeful ideals and judicious language which insulated it somewhat (though hardly enough!) from the prejudices of their day. To say that our current interpretation of their words should be confined to whatever psychoanalysis we can make of their meanings at the time would lock our whole political and legal system into those same prejudices that they were trying to overcome. To take the second amendment, Mystal argues (I am not sure how successfully) that its "militias" were most keenly understood to mean bands of Southern planters gathering together to prevent or put down slave revolts. Southerners did not want to be dependent on Federal sympathy and arms, and thus insisted that a right to raise their own militias for their own peculiar needs should be enshrined in the constitution. Well, if we were to restrict outselves to such an interpretation, that would have significant effects on our practice of the second amendment. Gun control would be allowed in the North, just not in the South, allowing guns to white males with certain property qualifications, perhaps, and certain mental proclivities.

Even the civil war amendments would be infected with originalism, since very few people at that time envisioned the full social equality of black citizens. It is remarkable to consider the flurry of anti-miscegenation laws passed during the Jim Crow era, after the Southern slave owners had spent a century or two conducting forced miscegenation. Whence the squeemishness? Anyhow, consistent originalism would never have struck down such laws, or abetted the civil rights movement for blacks, let alone gays. Mystal imagines the nettlesome questioning of a prospective conservative justice going like: "Do you believe that Loving v. Virgina was rightly decided?" This case was about the social system of the South, which Mystal tries to separate from the legal and political aspects, and clearly on originalist principles could not be decided as it was. And much more so on Obergefell, which draws on the fourteenth amendment's due process concept to free personal choices (of gay people) from government intrusion, again doubtless totally in contradiction to the social vision and intention of any of its authors.

Instead of fixating on the past so much, in constitutional interpretation, we might think about the future more.

So originalism, for all its rhetorical seductiveness, (after one has been properly indoctrinated in the divine virtues of the founding fathers), is an absurdity for a country with even the tiniest ambition towards social progress, or change of any kind. It amounts to extreme conservatism, pure and simple. Mystal is relentlessly dismissive of the conservative mindset, tied as it is (ever more explicitly in our polarized moment) to regressive, even violent, racial anti-minority politics. 

What is the deal with conservatives? I think there is another unenumerated right that undergirds all these tensions, which is the right to win, and win by inheriting what our forebears wrought- physically, monetarily, politically, socially. America is a highly competitive country- we compete in making money, in politics, in sports, in war. In any society there is an inherent tension between the cohesiveness required to build common structures, like a constitution, or a military, and the the competitiveness that, if channeled properly, can also build great things, but if let loose, can tear down everything. The right to succeed in business, and to bequeath those gains to one's children- that is a widely shared dream. Our founders saw that there had to be limits to this dream, however. The creaky aristocracies of Europe fed on centuries of priviledge and inheritance. America was fundamentally opposed to noble privileges, but in their slaveholding and other businesses, the founders were far from averse to hereditary privileges in general.

It was the whites who won all this- won the American continent from its native inhabitants, won the slaves from their native hearths, invented the technologies like the cotton gin, devised the capitalist system, etc., etc. Who has a right to inherit all these winnings? Conservatives subscribe to a fundamentally competitive system. That is why Trump won the hearts of a rabid base. Lying isn't a bug, it is a feature, an intrinsic part of winning in a duplicitous cultural competition- and winning is everything. To conservatives, social justice is a fundamental affront. Who said the world was fair? Not us! Constitutional originalism is way of expressing this denial of social progress and justice in concrete, and superficially palatable, terms. For as Mystal reiterates, the justices are not calling balls and strikes- constitutional interpretation runs rather freely, as we can see from second amendment jurisprudence. That is why capture of the supreme court has been such a existential project of the right for decades.

Counterpoised to the conservative conception of (lack of) justice in America is that of the left, perhaps best exemplified by the California Reparations task force. If one looks back and considers the losses of enslaved and oppressed Americans, one quickly reaches astronomical levels of reparations that would be required in a just world. How to make up for death and torture? How to make up for the bulldozing of entire communities? How to make up for centuries of economic, social, political, and legal disadvantage? There is simply no way to make up what has been lost, and to do so would open up many other claims, especially by Native Americans, all inhabitants of Vietnam, Iraq, and Afghanistan, not to mention countless other victims of historical processes going back centuries and ranging world-wide. Justice is a massive can of worms, if looking back in time. But how about something simple, like affirmative action, giving formerly oppressed people a small leg up in the current system? Conservatives can't stand that either, and cry anti-white racism. 

It frankly boggles the mind, how greedy some people can be. But I think the problem of inheritance remains a central touchstone. In each generation, does everyone share equally in the inheritances from the past, or does one race inherit more, do children of the rich inherit more, do the well-connected send their children into the halls of power? The only way to insure a fresh and fair start for each generation is to, not only demolish the idea of inherited nobility as our founders did, (and which we are edging back toward with extreme economic inequality), but go a little beyond that to end other forms of inheritance ... of money and power. The meritocratic systems of higher education did a great deal in the twentieth century to advance this ideal, allowing students from all backgrounds to aspire to, and achieve, all kinds of success. This made the US incredibly powerful and the envy of the world. Liberals should continue this tradition by attacking all forms of entrenched and inherited power, from private schools to the shameful lack of inheritance taxation. The better way to make reparations is to pay it forward, with more just future world.

• Entering blackness.
• "Private jets are on average 10 times more carbon intensive than commercial flights"
• The perils of ransomware.
• The incredible and thoughtless craven-ness of Republicans.
• Our problem with futile medicine.
• Wow- lots of papers (in bad science journals) are duplicated, plagiarized, or fake ... the paper mills.

For the Love of Money

The social magic of wealth ... and Trump's travel down the wealth / status escalator.

I have been reading the archly sarcastic "The Theory of the Leisure Class", by Thorstein Veblen. It introduced the concept of "conspicuous consumption" by way of arguing that social class is marked by work, specifically by the total lack of work that occupies the upper, or leisure class, and more and more mundane forms of work as one sinks down the social scale. This is a natural consequence of what he calls our predatory lifestyle, which, at least in times of yore, reserved to men, especially those of the upper class, the heroic roles of hunter and warrior, contrasted with the roles of women, who were assigned all non-heroic forms of work, i.e. drudgery. This developed over time into a pervasive horror of menial work and a scramble to evince whatever evidence one can of being above it, such as wearing clean, uncomfortable and fashionable clothes, doing useless things like charity drives, golf, and bridge. And having one's wife do the same, to show how financially successful one is.

Veblen changed our culture even as he satarized and skewered it, launching a million disgruntled teenage rebellions, cynical movies, songs, and other analyses. But his rules can not be broken. Hollywood still showcases the rich, and silicon valley, for all its putative nerdiness, is just another venue for social signaling by way of useless toys, displays of leisure (at work, no less, with the omnipresent foosball and other games), and ever more subtle fashion statements.

Conversely, the poor are disparaged, if not hated. We step over homeless people, holding our noses. The Dalit of India are perhaps the clearest expression of this instinct. But our whole economic system is structured in this way, paying the hardest and most menial jobs the worst, while paying some of the most social destructive professions, like corporate law, the best, and placing them by attire, titles, and other means, high on the social hierarchy.

As Reagan said, nothing succeeds like success. We are fascinated, indeed mesmerized, by wealth. It seems perfectly reasonable to give wealthy areas of town better public services. It seems perfectly reasonable to have wealthy people own all our sports teams, run all our companies, and run for most political offices. We are after all Darwinian through and through. But what if a person's wealth comes from their parents? Does the status still rub off? Should it? Or what if it came from criminal activities? Russia is run by a cabal of oligarchs, more or less- is their status high or low?

All this used to make more sense, in small groups where reputations were built over a lifetime of toil in support of the family, group, and tribe. Worth was assessed by personal interaction, not by the proxy of money. And this status was difficult to bequeath to others. The fairy tale generally has the prince proving himself through arduous tasks, to validate the genetic and social inheritance that the rest of the world may or may not be aware of. 

But with the advent of money, and even more so with the advent of inherited nobility and kingship, status became transferable, inheritable, and generally untethered from the values it supposedly exemplifies. Indeed, in our society it is well-known that wealth correlates with a decline in ethical and social values. Who exemplifies this most clearly? Obviously our former president, whose entire public persona is based on wealth. It was evidently inherited, and he parlayed it into publicity, notariety, scandal, and then the presidency. He was adulated, first by tabloids and TV, which loved brashness (and wealth), then by Republican voters, who appear to love cruelty, mean-ness, low taste and intellect, ... and wealth. 

But now the tide is slowly turning, as Trump's many perfidies and illegal practices catch up with him. It is leaking out, despite every effort of half the media, that he may not be as wealthy as he fraudulently portrayed. And with that, the artificial status conferred by being "a successful businessman" is deflating, and his national profile is withering. One might say that he is taking an downward ride on the escalator of social status that is in our society conferred largely by wealth.

All that is shiny ... mines coal.

Being aware of this social instinct is naturally the first step to addressing it. A century ago and more, the communists and socialists provided a thoroughgoing critique of the plutocratic class as being not worthy of social adulation, as the Carnegies and Horatio Algers of the world would have it. But once in power, the ensuing communist governments covered themselves in the ignominy of personality cults that facilitated (and still do in some cases) even worse political tyrannies and economic disasters. 

The succeeding model of "managed capitalism" is not quite as catastrophic and has rehabilitated the rich in their societies, but one wouldn't want to live there either. So we have to make do with the liberal state and its frustratingly modest regulatory powers, aiming to make the wealthy do virtuous things instead of destructive things. Bitcoin is but one example of a waste of societal (and ecological) resources, which engenders social adulation of the riches to be mined, but should instead be regulated out of existence. Taking back the media is a critical step. We need to reel back the legal equation of money with speech and political power that has spread corruption, and tirelessly tooted its own ideology of status and celebrity through wealth.

• California police could use some supervision too.
• Marin- a cruel gerontocracy?

Sex in the Brain

The cognitive effects of gonadotropin-releasing hormone.

If you watch the lesser broadcast TV channels, there are many ads for testosterone- elixir of youth, drive, manliness, blaring sales pitches, etc. Is it any good? Curiously, taking testosterone can cause alot of sexual dysfunctions, due to feedback loops that carefully tune its concentration. So generally no, it isn't much good. But that is not to say that it isn't a powerful hormone. A cascade of other events and hormones lead to the production of testosterone, and a recent paper (review) discussed the cognitive effects of one of its upstream inducers, gonadotropin-releasing hormone, or GnRH. 

The story starts on the male Y chromosome, which carries the gene SRY. This is a transcription activator that (working with and through a blizzard of other regulators and developmental processes) is ultimately responsible for switching the primitive gonad to the testicular fate, from its default which is female / ovarian. This newly hatched testis contains Sertoli cells, which secrete anti-Mullerian hormone (AMH, a gene that is activated by SRY directly), which in the embryo drives the regression of female characteristics. At the same time testosterone from testicular Leydig cells drives development of male physiology. The initial Y-driven setup of testosterone is quickly superceded by hormones of the gonadotropin family, one form of which is provided by the placenta. Gonadotropins continue to be essential through development and life to maintain sexual differentiation. This source declines by the third trimester, by which time the pituitary has formed and takes over gonadotropin secretion. It secretes two gondotropin family members, follicular stimulating hormone (FSH) and leutinizing hormone (LH), which each, despite their names, actually have key roles in male as well as female reproductive development and function. After birth, testosterone levels decline and everything is quiescent until puberty, when the hormonal axis driven by the pituitary reactivates.

Some of the molecular/genetic circuitry leading to very early sex differentiation. Note the leading role of SRY in driving male development. Later, ongoing maintenance of this differentiation depends on the gonadotropin hormones.

This pituitary secretion is in turn stimulated by gonadotropin releasing hormone (GnRH), which is the subject of the current story. GnRH is produced by neurons that, in embryogenesis, originate in the nasal / olfactory epithelium and migrate to the hypothalamus, close enough to the pituitary to secrete directly into its blood supply. This circuit is what revs up in puberty and continues in fine-tuned fashion throughout life to maintain normal (or declining) sex functions, getting feedback from the final sex hormones like estrogen and testosterone in general circulation. The interesting point that the current paper brings up is that GnRH is not just generated by neurons pointing at the pituitary. There is a whole other set of neurons in the hypothalamus that also secrete GnRH, but which project (and secrete GnRH) into the cortex and hippocampus- higher regions of the brain. What are these neurons, and this hormone, doing there?

The researchers note that people with Down Syndrome characteristically have both cognitive and sexual defects resembling incomplete development, (among many other issues), the latter of which resemble or reflect a lack of GnRH, suggesting a possible connection. Puberty is a time of heightened cognitive development, and they guessed that this is perhaps what is missing in Down Syndrome. Down Syndrome typically winds up in early-onset Alzheimer disease, which is also characterized by lack of GnRH, as is menopause, and perhaps other conditions. After going through a bunch of mouse studies, the researchers supplemented seven men affected by Down Syndrome with extra GnRH via miniature pumps to their brains, aimed at target areas of this hormone in the cortex. It is noteworthy that GnRH secretion is highly pulsitile, with a roughly 2 hour period, which they found to be essential for a positive effect. 

Results from the small-scale intervention with GnRH injection. Subjects with Down Syndrome had higher cortical connectivity (left) and could draw from a 3-D model marginally more accurately.

The result (also seen in mouse models of Down Syndrome and of Alzheimer's Disease) was that the infusion significantly raised cognitive function over the ensuing months. It is an amazing and intriguing result, indicating that GnRH drives significant development and supports ongoing higher function in the brain, which is quite surprising for a hormone thought to be confined to sexual functions. Whether it can improve cognitive functions in fully developed adults lacking impeding developmental syndromes remains to be seen. Such a finding would be quite unlikely, though, since the GnRH circuit is presumably part of the normal program that establishes the full adult potential of each person, which evolution has strained to refine to the highest possible level. It is not likely to be a magic controller that can be dialed beyond "max" to create super-cognition.

Why does this occur in Down Syndrome? The authors devote a good bit the paper to an interesting further series of experiments, focusing on regulatory micro-RNAs, several of which are encoded in genomic regions duplicated in Down Syndrome. microRNAs are typically regulators that repress transcription, explaining how this whole circuitry of normal development, now including key brain functions, is under-activated in those with Down Syndrome.

The authors offer a subset of regulatory circuitry focusing on micro-RNA repressors of which several are encoded on the trisomic chromosome regions.

"HPG [hypothalamus / pituitary / gonadal hormone] axis activation through GnRH expression at minipuberty (P12; [the phase of testoserone expression in late mouse gestation critical for sexual development]) is regulated by a complex switch consisting of several microRNAs, in particular miR-155 and the miR-200 family, as well as their target transcriptional repressor-activator genes, in particular Zeb1 and Cebpb. Human chromosome 21 and murine chromosome 16 code for at least five of these microRNAs (miR-99a, let-7c, miR-125b-2, miR-802, and miR-155), of which all except miR-802 are selectively enriched in GnRH neurons in WT mice around minipuberty" - main paper

So, testosterone (or estrogen, for that matter) isn't likely to unlock better cognition, but a hormone a couple of steps upstream just might- GnRH. And it does so not through the bloodstream, but through direct injection into key areas of the brain both during development, and also on an ongoing basis through adulthood. Biology as a product of evolution comprises systems that are highly integrated, not to say jury-rigged, which makes biology as a science difficult, being the quest to separate all the variables and delineate what each component and process is doing.

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